Well, when I first noticed the quote on Kotaku, I got all excited but then I actually though about it. Said Yu Suzuki of Shenmue III, "Probably Sega will let me make it. I think. It's simply a problem of budget." That's the thing. It's always a problem of budget. I'm not sure how well Sega is doing financially these days but the economy is tough and it will have to be proven to be a viable proposition first. It starts with the forthcoming Smartphone game and I would expect that the original two games would have to be released over either PSN or XBOX Live to gauge interest and well, remind people that it exists, it has been eight years since Shenmue II's release for XBOX. It would likely only be single platform because it won't be profitable enough for both the PS3 and 360.
In conclusion, I'm downplaying this because I think he was just trying to throw a bone for all us loyal fans. Of course he wants to make it - it's his dream, his grand vision. Market realities tell a different story. Also, I don't want to get my hopes up, especially after the failure of Shenmue Online. Let's see if the Gaiden game even makes it to the west first. I think we who have been riding this horse all along are jaded enough by now to view this for what it probably is; a mirage.
Gamasutra article on Yu Suzuki's comments at GDC 2011.